Meet the Team: Jaein Park, PhD – Crossing Oceans to Drive FOXG1 Research

Jaein Park, PhD and PhD student Dongjun Shin at the 27th ASGCT meeting in May 2024

At the FOXG1 Research Center, each researcher brings their unique journey, dedication, and expertise to the lab’s mission of advancing treatments for FOXG1 Syndrome. This month, we’re honored to introduce Dr. Jaein Park, whose decision to move halfway across the world—from Korea to Buffalo—embodies his deep commitment to making a difference.

From a Childhood Dream to a Scientific Calling

Dr. Jaein Park’s fascination with science began in his early years, sparked by a love of dinosaurs. While his initial dream was to become an archeologist, his path shifted toward cell biology, a field where he could explore the mysteries of life on a cellular level.

After earning his degree in cell biology from Korea University, Jaein began working in a research lab focused on inflammation in cancer. Despite his efforts, he found himself frustrated by the lack of tangible breakthroughs.

“The receptors we studied were so complex, and it was difficult to connect them to a direct cure,” Jaein explained.

While the work was meaningful, he felt limited by the tools available and began searching for opportunities where he could make a more significant impact.

A Life-Changing Leap: Moving to Buffalo for FOXG1 Research

In 2019, Jaein came across a research paper authored by The Lees, founders of the FOXG1 Research Center. Their groundbreaking work immediately resonated with him, and he knew he wanted to be part of their mission. Driven by this vision, he reached out to the lab and secured a position—a decision that would change his life.

Relocating to Buffalo was no small feat. Jaein left behind his home, family, and career in Korea to join the FOXG1 team.

“It was a realistic but bold decision,” he shared. “I wanted to work in a lab with advanced tools and cutting-edge techniques, and I saw that opportunity with The Lees.”

Adjusting to life in Buffalo was a positive experience for Jaein, who described it as a breath of fresh air—literally.

“The environment here is great,” he said. “The air is fresh, and the temperatures are not as cold as in Korea. I love it here.”

A Challenging Start and a Turning Point

The early years at the FOXG1 Research Center weren’t without challenges.

“The first two years were really frustrating,” Jaein recalled.

One of his initial projects did not yield favorable results, leaving him uncertain about how he could contribute to the team’s mission.

Everything changed when he began working on the AAV9-FOXG1 gene therapy project. This initiative, which uses an advanced viral delivery system to target the FOXG1 gene, reignited his passion for research and allowed him to play a key role in one of the lab’s most promising efforts.

“This project was a turning point for me,” Jaein shared. “Before this, I worked on a variety of experiments—cell culture, mitochondrial studies—but AAV9 was different. For the first time, I felt like I was contributing to something directly connected to curing a human disease.”

Jaein’s role in the project is multifaceted, involving imaging, EEG analysis, and virus-related experiments. He has also been instrumental in developing techniques for analyzing seizure patterns in FOXG1 mutant mice, helping the team better understand the neurological effects of the syndrome.

Motivated by Hope and Progress

What keeps Jaein motivated is the clear goal of FOXG1 research: improving the lives of families affected by the syndrome.

“My previous research in cancer felt disconnected from tangible outcomes,” he explained. “But here, our work is focused on finding a cure. That’s incredibly motivating.”

The AAV9-FOXG1 project, which has shown visible effects in the brains of FOXG1 mutant mice, represents a significant step forward. Jaein is optimistic about the next phase of trials, a critical step toward bringing the therapy to human patients.

“We’re seeing promising results,” he said. “The virus experiments are showing visible effects for the first time, and I believe this could be the first step toward curing FOXG1 Syndrome in humans.”

Beyond the Lab

When he’s not in the lab, Jaein enjoys watching movies to unwind. This simple hobby helps him recharge and maintain balance, allowing him to stay focused on the challenging and rewarding work of research.

A Message to the FOXG1 Community

For Jaein, the trust and hope placed in the lab by families affected by FOXG1 Syndrome are both a privilege and an immense responsibility.

“I feel an immense responsibility, but I’m also proud,” he said. “Our research is the first step toward treating this disease. There may be challenges along the way, but we are doing everything we can to achieve our goal.”

Looking Ahead

Jaein is optimistic about the future of FOXG1 research. As the team prepares for the next phase of trials, he’s hopeful the lab’s special virus will pass toxicity tests and move closer to clinical application. He also recognizes the need to continue refining and expanding treatment options to ensure they are effective, safe, and accessible.

“This is just the beginning,” he said. “We’re working not only on this virus treatment but also on finding more efficient and easier ways to help FOXG1 patients. It will take time, but I’m confident we’ll get there.”

Conclusion

Dr. Jaein Park’s journey from Korea to Buffalo is a testament to his unwavering dedication to science and his belief in the power of collaboration and innovation. His work at the FOXG1 Research Center has already made a profound impact, and his contributions will continue to be a driving force in the lab’s mission to bring hope and healing to families affected by FOXG1 Syndrome.

Jaein at The Statue of Liberty